High molecular weight vs low molecular weight sodium hyaluronate

What are the different effects of different molecular weights of sodium hyaluronate in the treatment of knee osteoarthritis?

Knee osteoarthritis (KOA) is a common chronic joint disease with an increasing prevalence among older adults, severely impacting quality of life. Sodium hyaluronate (SH), as a core component of synovial fluid, is a key drug in KOA treatment. However, different molecular weights of SH exhibit significant differences in efficacy and mechanism of action, directly affecting treatment options. This article focuses on interpreting its differentiating effects to provide a reference for clinical application. [Reference Interpretation: Figure 1]