What Molecular Weight of Hyaluronic Acid is Best for Skin?

Hyaluronic acid (HA) is a widely used ingredient in skincare, valued for its ability to hydrate and plump the skin. However, the molecular weight of hyaluronic acid significantly impacts its effectiveness. Different molecular weights serve distinct functions, making it crucial to choose the right type based on skincare needs.

High-Molecular-Weight Hyaluronic Acid (HMW-HA, >1000 kDa) remains on the surface of the skin, forming a breathable hydration film that reduces transepidermal water loss (TEWL). It provides immediate skin hydration and soothes irritation by reinforcing the skin barrier. This type of HA is ideal for individuals with sensitive or dry skin who need surface-level moisture and protection.

Medium-Molecular-Weight Hyaluronic Acid (MMW-HA, 300-1000 kDa) offers balanced hydration and anti-inflammatory benefits. It penetrates slightly deeper than HMW-HA, improving skin elasticity while still maintaining a protective function. This weight range is often found in products designed for overall skin health and anti-aging benefits.

Low-Molecular-Weight Hyaluronic Acid (LMW-HA, <300 kDa) can penetrate into deeper layers of the epidermis, promoting longer-lasting hydration and improving skin firmness. It stimulates the skin's repair mechanisms and enhances elasticity. 

Ultra-Low-Molecular-Weight Hyaluronic Acid (<10 kDa) can reach even deeper layers of the skin, stimulating collagen production and enhancing skin renewal. This type is particularly beneficial for anti-aging formulations, as it helps improve skin density and reduce fine lines over time.

Which One Is Best? The best molecular weight depends on individual skincare goals. High-molecular-weight HA is excellent for hydration and barrier support, while low-molecular-weight HA is more effective for deep hydration and anti-aging. Many skincare formulations use a combination of different molecular weights to maximize benefits.

Focusfreda, with over 30 years of expertise in sodium hyaluronate production, provides high-quality HA raw materials tailored for various skincare applications. Our advanced technology ensures precise molecular weight distribution to optimize skincare performance.