When it comes to skincare, two popular ingredients are Vitamin B5 (Panthenol) and Hyaluronic Acid (Sodium Hyaluronate). Many people ask: Can you use them together? The answer: Yes, and they work even better as a pair.

What Is Vitamin B5?

Vitamin B5, often shown as Panthenol on labels, is a hydrating and soothing ingredient. It:
Attracts and holds water.
Keeps skin soft and smooth.
Supports barrier repair.
Calms irritation.

This makes it common in serums, creams, and lotions for dry or sensitive skin.

What Is Hyaluronic Acid?

Hyaluronic Acid is a natural molecule that can bind up to 1,000 times its weight in water. In products, it’s used as Sodium Hyaluronate, which is stable and effective:
High molecular weight: Creates a hydrating layer on the surface.
Low molecular weight: Penetrates deeper for long-lasting hydration.

This layered effect explains why it’s so popular in serums, toners, and creams.

Why Use Them Together?

Combining Vitamin B5 and Hyaluronic Acid delivers:
Deep hydration from both humectants.
Barrier support — B5 repairs, HA locks in water.
Soothing care for sensitive or irritated skin.
Better absorption, maximizing benefits.

How to Use Them

You’ll often see them together in hydrating serums and creams. Or you can layer:
Apply a Hyaluronic Acid serum on damp skin.
Follow with a B5 moisturizer or serum.
Both are gentle, safe, and suitable for daily use.

Final Thoughts

Yes — Vitamin B5 and Hyaluronic Acid are safe and effective together. This duo improves hydration, barrier repair, and skin comfort, making it a smart choice for a healthy skincare routine.

At Focusfreda, we supply sodium hyaluronate from 400 Da to 3 million Da and provide formulation suggestions that combine HA with B5 to meet diverse product needs.