Which Major Brands Use Hyaluronic Acid?

Hyaluronic Acid (HA) – and its salt form sodium hyaluronate – shows up everywhere: in moisturisers and serums, dermal fillers, eye drops, knee injections for osteoarthritis, wound-healing products and dietary supplements.

That’s partly because HA is a sugar molecule naturally found in mammalian skin, eyes and joint fluid, where it binds large amounts of water and cushions tissues.

Its “already-in-your-body” status gives it a strong biocompatibility profile when purified and used appropriately, which is why so many leading brands build products around it.

Below is a practical, brand-by-brand tour of HA’s main application fields. (Lists are illustrative “top players”, not a strict ranking.)

Which Skin Care & Cosmetics Brands Use Hyaluronic Acid?

Hyaluronic acid is best known for its moisturizing properties. Major mass-market and professional beauty brands typically sell serums, gels, and creams containing hyaluronic acid or sodium hyaluronate, often emphasizing terms like "hydrating and rejuvenating," "revitalizing and firming," and "hyaluronic acid" on the packaging. Three to five years ago, a striking phenomenon was observed in Korean skincare stores, where shelves dedicated to face masks were filled with various products bearing the letters "HA."

Representative Skincare Brands Using Hyaluronate Acid

Why Is Hyaluronic Acid Used in Aesthetic Injectables (Dermal Fillers & Skin Boosters)?

Hyaluronic acid has become a star ingredient in modern cosmetic injectables for a simple reason: its function is almost identical to the moisturizing layer naturally present in our skin. After injection, hyaluronic acid acts like a miniature absorbent sponge, absorbing and locking in moisture, instantly restoring skin plumpness, smoothing fine lines, and revitalizing tired skin. Its soft gel texture blends perfectly with facial tissue, making the effect look natural, not like a "filler" mark. 

Whether sculpting the jawline, plumping lips, reshaping the nose, or deeply hydrating through skin-strengthening agents, hyaluronic acid provides precise, flexible, and fresh-looking results. This versatile molecule has become a key ingredient in today's dermal fillers and injectable skincare products.

Major HA Dermal Fillers / Skin Boosters Brands

What Brands Offer Osteoarthritis Knee Injections (Viscosupplementation)?

In orthopaedics, intra-articular HA injections (viscosupplements) are used to relieve knee osteoarthritis pain when simple painkillers and non-drug options aren’t enough. These products supplement degraded native HA in synovial fluid to improve lubrication and shock absorption.

Again: these are prescription-only medical products that must be administered by a doctor.

Representative HA Knee-injection Brands

Why Is Hyaluronic Acid Used In Eye Care And Eye Surgery?

Hyaluronic Acid's water-binding and viscoelastic properties make it ideal for:

· Dry-eye artificial tears (sodium hyaluronate for lubrication)

· Ophthalmic viscoelastic devices (OVDs) used during cataracts and other surgeries to protect ocular tissues (Like a transparent "jelly" injected into the eye, it can steadily support and protect the delicate intraocular tissues, making it a valuable assistant to doctors.)

Manufacturers of general eye drops and ocular viscoelastic agents directly purchase eye drop-grade sodium hyaluronate for manufacturing. This special raw material has higher requirements for market access in various countries, typically focusing on low endotoxin content.

Leading Brands Of HA-Based Drops Or OVDs

Which Dietary Supplement (Joint And Skin Support) Brands Choose To Add Food-grade Hyaluronic Acid?

Oral hyaluronic acid supplements combine hyaluronic acid with collagen, chondroitin, or plant extracts, and are marketed for relieving joint discomfort and moisturizing the skin. While the evidence for their efficacy is not as robust and direct as that of injectable supplements, some studies suggest that certain formulations of oral hyaluronic acid supplements can improve skin hydration or relieve knee pain in the long term.

Representative Supplement Brands Containing Hyaluronic Acid

Why So Many Brands Use HA – And What That Means for the Market?

A few big reasons explain why hyaluronic acid has become a cross-industry workhorse:

It’s endogenous to mammals. HA is naturally present in human and animal skin, synovial fluid, and the vitreous body of the eye, acting as a structural and lubricating component.

Excellent water-binding & viscoelasticity. A single HA chain can bind up to ~1,000 times its weight in water, giving plumpness to skin and viscosity to joint fluid – attributes exploited in moisturisers, fillers, eye drops and knee injections.

Versatile formulations. By varying molecular weight, cross-linking and route of administration (topical, injectable, oral), companies can target hydration, cushioning, volume, or slow release of other actives.

Because of these attributes – plus an ageing population, high demand for aesthetic procedures, and growing interest in “joint health” and “beauty from within” – analysts project that the global hyaluronic acid market will continue to grow at a healthy mid-single to high-single-digit CAGR into the 2030s, with medical and cosmetic uses both contributing substantially.

Reliable Products Originate From Safe Raw Materials? The Answer Is Always Yes.

To support this growth, brands increasingly partner with specialised raw-material suppliers such as Shandong FocusFreda Biotech Co., Ltd. FocusFreda is a dedicated sodium hyaluronate fermentation manufacturer, providing high-purity HA for cosmetic, nutrition and medical-beauty applications in more than 70 countries. 

Its bio-fermentation–derived sodium hyaluronate API holds EU CEP certification, and the company’s ESG-oriented factories emphasise efficient resource use and reduced emissions, ensuring a stable and sustainable high-quality HA supply.